The man, whose wife, son, daughter and niece, were also infected with the dreaded disease, died before dawn on April 8 at Phay Hospital in Bago Region, according to Dr. Khin Khin Gyi.
The cause of death was respiratory failure with septicemia, a case of blood poisoning, due to COVID-19, she said.
The victim was the deputy administrator of the General Administration Department in Pauk Khaung township in Bago.
His wife, who is a nurse at a private clinic in Bahan township in Yangon, was the first in the family diagnosed with the disease.
The 63-year-old woman was among the recently confirmed COVID-19 patient in the country who went to the Yangon International Airport on March 15 to meet her son who arrived from Dubai.
The woman, who is suffering from diabetes, was admitted at the North Okkalapa General Hospital on March 31 after she developed fever, cough and experience tiredness.
She died on April 8 while being treated at Wai Bar Gi Hospital in Yangon.
The first COVID-19 fatality in Myanmar was a 69-year-old man who went to Australia to seek treatment for his nasal cancer. He died on March 31 at a hospital in Yangon.
Two of the remaining 19 COVID-19 patients in the country appear to be on the road to recovery after new tests showed they were negative for the virus.
One of them is a 33-year-old Mandalay man who is a US citizen, the other is a United Nations worker assigned in Myanmar.
Last week, the Myanmar government appealed to the international community for medical equipment and supplies needed to fight the pneumonia-like disease.
While there has yet an outbreak of the disease in the country, local authorities are particularly worried that a spike in the number of confirmed cases could increase following the return of tens of thousands of Myanmar migrant workers from abroad, especially from Thailand.